There were no interventions beyond the routine therapy determined by their clinicians on the basis of standard clinical practice. The data were analyzed between Jun 2020 and Mar 2021. Screening of brain regions with significant changes in fALFF values was based on analysis of the whole brain. Methods: All participants underwent magnetic resonance imaging (MRI) and cognitive assessment (digit span and digit symbol coding tests). Objectives: We aim to detect the fractional amplitude of low-frequency fluctuation (fALFF) alterations in patients with schizophrenia, and examine how their behavior correlates in relation to the cognitive impairments of the patients. However, the effects of lentiform nucleus function on cognitive impairments in schizophrenia are yet to be investigated. Holding a role in various aspects of cognition, lentiform nucleus (putamen and globus pallidus) dysfunction contributes to the psychopathology of this disease. Introduction: Cognitive decline is the core schizophrenia symptom, which is now well accepted.

5Department of Radiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China.

4Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi’an, China.

3Department of Clinical Psychology, School of Medical Psychology, The Fourth Military Medical University, Xi’an, China.

2Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi’an, China.

1Medical Imaging Department 1, Xi’an Mental Health Center, Xi’an, China.

Ping Li 1, Shu-Wan Zhao 2, Xu-Sha Wu 2, Ya-Juan Zhang 3, Lei Song 3, Lin Wu 3, Xiao-Fan Liu 2, Yu-Fei Fu 2, Di Wu 4, Wen-Jun Wu 4, Ya-Hong Zhang 4, Hong Yin 2, Long-Biao Cui 3,5* and Fan Guo 2*

Lenticular effects v4.1